The medical field continues to be amazed that people are different. More, that different people groups are different. This study found that black women with PCOS have an elevated risk of metabolic syndrome when compared to white women with PCOS. Body weight was a variable that was controlled for. This was a retrospective study.
Statin therapy worsens insulin sensitivity and thus glucose regulation in women with PCOS. Women with PCOS are at increased risk for type II Diabetes. Statins interfere with glucose metabolism and thus will increase the effective risk for these women. This study was a randomized, prospective study.
low grade, chronic inflammation associated with PCOS and common disease states associated with PCOS. It is known that high androgen levels in women causes inflammation.
women with PCOS, inflammatory cytokines TNF-alpha and CRP, associated with increasing androgen levels and with abdominal fat. Women with less fat had lower levels of TNF-alpha and CRP than their higher weight counterparts, though the inflammatory cytokines were still evident.
It is well known that obesity increases CRP. However, in this meta-analysis, CRP elevation in women with PCOS was found to be independent from obesity and as they concluded: "...chronic low-grade inflammation that may underpin the pathogenesis of this disorder".
In women with PCOS, inflammation DIRECTLY stimulates androgen production from the ovaries. Inflammation is the driving force behind the high androgen levels in women with PCOS.